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Biopsy of joint synovium found villous nodules, the invasion of foam cells, and hemosiderin deposition. Magnetic resonance imaging (MRI) revealed synovial thickening and hemosiderin deposition. Puncture fluid from a shoulder joint was bloody. Physical examination revealed multiple joints swelling, especially in the shoulders joints. The patient was then transferred to our hospital. However, the treatment had no effect, the joints swelling remained. Naproxen, methotrexate, infliximab, and pavlin were used to treat the patient for 2 months. She was diagnosed as polyarticular juvenile idiopathic arthritis at a local hospital. Clinical procedure:Ī 7-year-old female patient had a 6-month history of multifocal joints swelling with mild pain.

We reported a rare case of multifocal PVNS affecting over 20 joints in a child. Multifocal PVNS is very rare, particularly in childhood. Pigmented villonodular synovitis (PVNS) is a rare, benign proliferative disorder of the synovial membrane that typically presents in adults and affects a single joint. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

81330016) and the Subject of Sichuan Provincial Department of Health (No.

Written informed consent was obtained from the parents of the patient for publication of this case report and any accompanying images.įunding: This work was supported by grants from the National Science Foundation of China (No. BKey Laboratory of Ministry of Education for Obstetric & Gynecologic and Pediatric Diseases and Birth Defects, West China Second University Hospital, Sichuan University, Chengdu, China.Ĭorrespondence: Dezhi Mu, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China (e-mail: ).Ībbreviations: HE = hematoxylin and eosin, MRI = magnetic resonance imaging, PVNS = pigmented villonodular synovitis.Ĭonsent: Ethical approval was obtained from the Ethics Committee of West China Second University Hospital, Sichuan University.